LA MICROBIOTA VAGINAL Y SU RELACIÓN EN EL DESARROLLO DE NEOPLASIA INTRAEPITELIAL CERVICAL
Palabras clave:
Microbiota Vaginal, Lactobacillus, Neoplasia Intraepitelial Cervical
Resumen
La microbiota vaginal se encuentra compuesta por diferentes tipos de microorganismos los cuales contribuyen a la homeostasis y protección contra infecciones. Sin embargo, la microbiota puede variar dependiendo de los cambios que se experimentan a lo largo de la vida de la mujer, especialmente durante la adolescencia, embarazo y menopausia, estas etapas se caracterizan por cambios hormonales. Esto coadyuva a modificaciones en el epitelio cervicovaginal y de esta manera es más propenso a enfermedades como la disbiosis vaginal y el desarrollo de neoplasia intraepitelial cervical. Es de interés abordar la relación que tiene la microbiota vaginal para el desarrollo de los distintos grados de neoplasia intraepitelial cervical, ya que la microbiota cervicovaginal es de gran importancia durante la vida de una mujer.
Citas
Barrientos-Durán A, Fuentes-López A, de Salazar A, Plaza-Díaz J, García F, Reviewing the Composition of Vaginal Microbiota: Inclusion of Nutrition and Probiotic Factors in the Maintenance of Eubiosis. Nutrients. 2020; 12 (2): 419.
Wang B, Yao M, Lv L, Ling Z, Li L. The human microbiota in health and disease. Engineering. 2017; 3 (1): 71-82.
Usyk M, Zolnik C.P, Castle P.E, Porras C, Herrero R, Gradissimo A, et al. Cervicovaginal microbiome and natural history of HPV in a longitudinal study. PLoS Pathogens. 2020; 16 (3): e1008376.
Quaranta G, Sanguinetti M, Masucci L. Fecal Microbiota Transplantation: A Potential Tool for Treatment of Human Female Reproductive Tract Diseases. Frontiers in Immunology. 2019; 10:2653.
Kwon M, Seo S, Kim M, Lee D, Lim M. Compositional and Functional Differences between Microbiota and Cervical Carcinogenesis as Identified by Shotgun Metagenomic Sequencing. Cancers. 2019; 11(3): 309.
Tao L, Han L, Li X, Gao Q, Pan L, Wu L, et al. Prevalence and risk factors for cervical neoplasia: a cervical cancer screening program in Beijing. BMC Public Health. 2014; 14 (1): 1185.
Muhleisen A.L, Herbst-Kralovetz M.M. Menopause and the vaginal microbiome. Maturitas. 2016; 91: 42-50.
Pramanick R, Mayadeo N, Warke H, Begum S, Aich P, Aranha C. Vaginal microbiota of asymptomatic bacterial vaginosis and vulvovaginal candidiasis: Are they different from normal microbiota?.Microbial pathogenesis. 2019; 134, 103599.
Klein C, Kahesa C, Mwaiselage J, West J.T, Wood C, Angeletti P.C. How the Cervical Microbiota Contributes to Cervical Cancer Risk in Sub-Saharan Africa. Frontiers in Cellular and Infection Microbiology. 2020; 10: 23.
Onywera H, Williamson A.L, Mbulawa Z.Z.A, Coetzee D, Meiring T.L. Factors associated with the composition and diversity of the cervical microbiota of reproductive-age Black South African women: a retrospective cross-sectional study. PeerJ. 2019; 7: e7488.
Innes C.R, Sykes P.H, Harker D, Williman J.A, Van der Griend R.A, Whitehead M, et al. Changes in human papillomavirus genotypes associated with cervical intraepithelial neoplasia grade 2 lesions in a cohort of young women (2013–2016). Papillomavirus Research. 2018; 6:77-82.
Kelly H, Weiss H.A, Benavente Y, de Sanjose S, Mayaud P, Qiao Y.l, et al. Association of antiretroviral therapy with high-risk human papillomavirus, cervical intraepithelial neoplasia, and invasive cervical cancer in women living with HIV: a systematic review and meta-analysis. The lancet HIV. 2018; 5 (1): e45-e58.
Tainio K, Athanasiou A, Tikkinen K.A.O, Aaltonen R, Cárdenas J, Glazer-Livson S, et al. Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis. BMJ. 2018; 360: k499.
Martin D.H, Marrazzo J.M. The vaginal microbiome: current understanding and future directions. The Journal of Infectious Diseases. 2016; 214 (suppl_1): S36-S41.
Castle P.E, Giuliano A.R. Chapter 4: Genital tract infections, cervical inflammation, and antioxidant nutrients—assessing their roles as human papillomavirus cofactors. Jnci Monographs. 2003; (31): 29-34.
Kyrgiou M, Mitra A, Moscicki A.-B. Does the vaginal microbiota play a role in the development of cervical cancer?. Translational Research. 2017; 179: 168-182.
Ma B, France M.T, Crabtree J, Holm J.B, Humphrys M.S, Brotman R.M, et al. A comprehensive non-redundant gene catalog reveals extensive within-community intraspecies diversity in the human vagina. Nature Communications. 2020; 11 (1): 1-13.
Muzny C.A, Łaniewski P, Schwebke J.R, Herbst-Kralovetz M.M. Host-vaginal microbiota interactions in the pathogenesis of bacterial vaginosis. Current Opinion in Infectious Diseases. 2020; 33 (1): 59.
Champer M, Wong A.M, Champer J, Brito I.L, Messer P.W, Hou J.Y. et al. The role of the vaginal microbiome in gynaecological cancer. BJOG: An International Journal of Obstetrics & Gynaecology. 2018; 125 (3): 309-315.
De Seta F, Campisciano G, Zanotta N, Ricci G, Comar M. The vaginal community state types microbiome-immune network as key factor for bacterial vaginosis and aerobic vaginitis. Frontiers in Microbiology. 2019; 10: 2451.
Hong X, Fang S, Huang K, Yin J, Chen J, Xuan Y, et al. Characteristics of the vaginal microbiome in cross-border female sex workers in China: a case-control study. PeerJ. 2019; 7: e8131.
Carda-Diéguez M, Cárdenas N, Aparicio M, Beltrán D, Rodríguez J.M, Mira A. Variations in vaginal, penile and oral microbiota after sexual intercourse: A case report. Frontiers in Medicine. 2019; 6: 178.
Arokiyaraj S, Seo S.S, Kwon M, Lee J.K, Kim M.K. Association of cervical microbial community with persistence, clearance and negativity of Human Papillomavirus in Korean women: a longitudinal study. Scientific Reports. 2018; 8 (1): 1-9.
Curty G, de Carvalho P.S, Soares M.A. The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer. International Journal of Molecular Sciences. 2020; 21 (1): 222.
Mendoza K.G, Kain W.C. Factores de riesgos en mujeres diagnosticadas con lesiones pre-malignas de cáncer cérvicouterino. Revista Universitaria del Caribe. 2018; 21 (2): 71-83.
Audirac-Chalifour A, Torres-Poveda K, Bahena-Roman M, Tellez-Sosa J, Martinez-Barnetche J, Cortina-Ceballos B, et al. Cervical microbiome and cytokine profile at various stages of cervical cancer: a pilot study. PloS One. 2016; 11 (4): e0153274.
Mitra A, MacIntyre D.A, Ntritsos G, Smith A, Tsilidis K.K, Marchesi J.R, et al. The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions. Nature Communications. 2020; 11 (1): 1-13.
Chorna N, Romaguera J, Godoy-Vitorino F. Cervicovaginal Microbiome and Urine Metabolome Paired Analysis Reveals Niche Partitioning of the Microbiota in Patients with Human Papilloma Virus Infections. Metabolites. 2020; 10 (1): 36.
Wang B, Yao M, Lv L, Ling Z, Li L. The human microbiota in health and disease. Engineering. 2017; 3 (1): 71-82.
Usyk M, Zolnik C.P, Castle P.E, Porras C, Herrero R, Gradissimo A, et al. Cervicovaginal microbiome and natural history of HPV in a longitudinal study. PLoS Pathogens. 2020; 16 (3): e1008376.
Quaranta G, Sanguinetti M, Masucci L. Fecal Microbiota Transplantation: A Potential Tool for Treatment of Human Female Reproductive Tract Diseases. Frontiers in Immunology. 2019; 10:2653.
Kwon M, Seo S, Kim M, Lee D, Lim M. Compositional and Functional Differences between Microbiota and Cervical Carcinogenesis as Identified by Shotgun Metagenomic Sequencing. Cancers. 2019; 11(3): 309.
Tao L, Han L, Li X, Gao Q, Pan L, Wu L, et al. Prevalence and risk factors for cervical neoplasia: a cervical cancer screening program in Beijing. BMC Public Health. 2014; 14 (1): 1185.
Muhleisen A.L, Herbst-Kralovetz M.M. Menopause and the vaginal microbiome. Maturitas. 2016; 91: 42-50.
Pramanick R, Mayadeo N, Warke H, Begum S, Aich P, Aranha C. Vaginal microbiota of asymptomatic bacterial vaginosis and vulvovaginal candidiasis: Are they different from normal microbiota?.Microbial pathogenesis. 2019; 134, 103599.
Klein C, Kahesa C, Mwaiselage J, West J.T, Wood C, Angeletti P.C. How the Cervical Microbiota Contributes to Cervical Cancer Risk in Sub-Saharan Africa. Frontiers in Cellular and Infection Microbiology. 2020; 10: 23.
Onywera H, Williamson A.L, Mbulawa Z.Z.A, Coetzee D, Meiring T.L. Factors associated with the composition and diversity of the cervical microbiota of reproductive-age Black South African women: a retrospective cross-sectional study. PeerJ. 2019; 7: e7488.
Innes C.R, Sykes P.H, Harker D, Williman J.A, Van der Griend R.A, Whitehead M, et al. Changes in human papillomavirus genotypes associated with cervical intraepithelial neoplasia grade 2 lesions in a cohort of young women (2013–2016). Papillomavirus Research. 2018; 6:77-82.
Kelly H, Weiss H.A, Benavente Y, de Sanjose S, Mayaud P, Qiao Y.l, et al. Association of antiretroviral therapy with high-risk human papillomavirus, cervical intraepithelial neoplasia, and invasive cervical cancer in women living with HIV: a systematic review and meta-analysis. The lancet HIV. 2018; 5 (1): e45-e58.
Tainio K, Athanasiou A, Tikkinen K.A.O, Aaltonen R, Cárdenas J, Glazer-Livson S, et al. Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis. BMJ. 2018; 360: k499.
Martin D.H, Marrazzo J.M. The vaginal microbiome: current understanding and future directions. The Journal of Infectious Diseases. 2016; 214 (suppl_1): S36-S41.
Castle P.E, Giuliano A.R. Chapter 4: Genital tract infections, cervical inflammation, and antioxidant nutrients—assessing their roles as human papillomavirus cofactors. Jnci Monographs. 2003; (31): 29-34.
Kyrgiou M, Mitra A, Moscicki A.-B. Does the vaginal microbiota play a role in the development of cervical cancer?. Translational Research. 2017; 179: 168-182.
Ma B, France M.T, Crabtree J, Holm J.B, Humphrys M.S, Brotman R.M, et al. A comprehensive non-redundant gene catalog reveals extensive within-community intraspecies diversity in the human vagina. Nature Communications. 2020; 11 (1): 1-13.
Muzny C.A, Łaniewski P, Schwebke J.R, Herbst-Kralovetz M.M. Host-vaginal microbiota interactions in the pathogenesis of bacterial vaginosis. Current Opinion in Infectious Diseases. 2020; 33 (1): 59.
Champer M, Wong A.M, Champer J, Brito I.L, Messer P.W, Hou J.Y. et al. The role of the vaginal microbiome in gynaecological cancer. BJOG: An International Journal of Obstetrics & Gynaecology. 2018; 125 (3): 309-315.
De Seta F, Campisciano G, Zanotta N, Ricci G, Comar M. The vaginal community state types microbiome-immune network as key factor for bacterial vaginosis and aerobic vaginitis. Frontiers in Microbiology. 2019; 10: 2451.
Hong X, Fang S, Huang K, Yin J, Chen J, Xuan Y, et al. Characteristics of the vaginal microbiome in cross-border female sex workers in China: a case-control study. PeerJ. 2019; 7: e8131.
Carda-Diéguez M, Cárdenas N, Aparicio M, Beltrán D, Rodríguez J.M, Mira A. Variations in vaginal, penile and oral microbiota after sexual intercourse: A case report. Frontiers in Medicine. 2019; 6: 178.
Arokiyaraj S, Seo S.S, Kwon M, Lee J.K, Kim M.K. Association of cervical microbial community with persistence, clearance and negativity of Human Papillomavirus in Korean women: a longitudinal study. Scientific Reports. 2018; 8 (1): 1-9.
Curty G, de Carvalho P.S, Soares M.A. The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer. International Journal of Molecular Sciences. 2020; 21 (1): 222.
Mendoza K.G, Kain W.C. Factores de riesgos en mujeres diagnosticadas con lesiones pre-malignas de cáncer cérvicouterino. Revista Universitaria del Caribe. 2018; 21 (2): 71-83.
Audirac-Chalifour A, Torres-Poveda K, Bahena-Roman M, Tellez-Sosa J, Martinez-Barnetche J, Cortina-Ceballos B, et al. Cervical microbiome and cytokine profile at various stages of cervical cancer: a pilot study. PloS One. 2016; 11 (4): e0153274.
Mitra A, MacIntyre D.A, Ntritsos G, Smith A, Tsilidis K.K, Marchesi J.R, et al. The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions. Nature Communications. 2020; 11 (1): 1-13.
Chorna N, Romaguera J, Godoy-Vitorino F. Cervicovaginal Microbiome and Urine Metabolome Paired Analysis Reveals Niche Partitioning of the Microbiota in Patients with Human Papilloma Virus Infections. Metabolites. 2020; 10 (1): 36.
Publicado
2022-05-17
Sección
Misceláneo
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